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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SIK2
All Species:
13.33
Human Site:
S292
Identified Species:
26.67
UniProt:
Q9H0K1
Number Species:
11
Phosphosite Substitution
Charge Score:
0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9H0K1
NP_056006.1
926
103915
S292
Q
E
Q
E
N
E
P
S
I
G
E
F
N
E
Q
Chimpanzee
Pan troglodytes
XP_508750
883
99166
S249
Q
E
Q
E
N
E
P
S
I
G
E
F
N
E
Q
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_546528
993
110460
S367
Q
G
Q
E
N
E
P
S
I
G
E
F
N
E
Q
Cat
Felis silvestris
Mouse
Mus musculus
Q8CFH6
931
104180
S292
Q
E
Q
E
N
E
P
S
I
G
E
F
N
E
Q
Rat
Rattus norvegicus
Q9R1U5
776
84890
P187
L
S
T
W
C
G
S
P
P
Y
A
A
P
E
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511894
801
88312
L213
V
W
S
L
G
V
V
L
Y
V
L
V
C
G
S
Chicken
Gallus gallus
Q9IA88
798
88848
G210
H
L
D
I
W
S
L
G
V
V
L
Y
V
L
V
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
Q6NSM8
1187
130949
E334
E
Q
V
K
V
E
R
E
T
E
L
I
N
E
Q
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_569972
1398
149888
N602
A
A
S
P
A
P
S
N
C
S
S
T
S
S
R
Honey Bee
Apis mellifera
XP_397175
718
80391
C130
I
L
S
A
V
E
Y
C
H
A
T
G
V
A
H
Nematode Worm
Caenorhab. elegans
Q9TW45
1192
126331
Q440
F
I
E
P
P
K
D
Q
I
D
E
Q
R
I
E
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P92958
512
58671
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
95.2
N.A.
84.7
N.A.
90.8
43.2
N.A.
45.2
45.4
N.A.
31.5
N.A.
29.6
37.4
23.8
N.A.
Protein Similarity:
100
95.3
N.A.
87.5
N.A.
94.4
56.7
N.A.
58.6
58.9
N.A.
45.2
N.A.
40
49.3
38.1
N.A.
P-Site Identity:
100
100
N.A.
93.3
N.A.
100
6.6
N.A.
0
0
N.A.
26.6
N.A.
0
6.6
13.3
N.A.
P-Site Similarity:
100
100
N.A.
93.3
N.A.
100
6.6
N.A.
0
13.3
N.A.
46.6
N.A.
20
6.6
33.3
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
24.1
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
37.4
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
0
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
9
9
0
9
9
0
0
0
0
9
9
9
0
9
0
% A
% Cys:
0
0
0
0
9
0
0
9
9
0
0
0
9
0
0
% C
% Asp:
0
0
9
0
0
0
9
0
0
9
0
0
0
0
0
% D
% Glu:
9
25
9
34
0
50
0
9
0
9
42
0
0
50
9
% E
% Phe:
9
0
0
0
0
0
0
0
0
0
0
34
0
0
0
% F
% Gly:
0
9
0
0
9
9
0
9
0
34
0
9
0
9
0
% G
% His:
9
0
0
0
0
0
0
0
9
0
0
0
0
0
9
% H
% Ile:
9
9
0
9
0
0
0
0
42
0
0
9
0
9
0
% I
% Lys:
0
0
0
9
0
9
0
0
0
0
0
0
0
0
0
% K
% Leu:
9
17
0
9
0
0
9
9
0
0
25
0
0
9
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
34
0
0
9
0
0
0
0
42
0
0
% N
% Pro:
0
0
0
17
9
9
34
9
9
0
0
0
9
0
0
% P
% Gln:
34
9
34
0
0
0
0
9
0
0
0
9
0
0
42
% Q
% Arg:
0
0
0
0
0
0
9
0
0
0
0
0
9
0
9
% R
% Ser:
0
9
25
0
0
9
17
34
0
9
9
0
9
9
9
% S
% Thr:
0
0
9
0
0
0
0
0
9
0
9
9
0
0
0
% T
% Val:
9
0
9
0
17
9
9
0
9
17
0
9
17
0
17
% V
% Trp:
0
9
0
9
9
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
9
0
9
9
0
9
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _